This story begins with a message from the past by the last two human hybrids who bring the beginning of the Paradox. These two humans are following orders from an advance alien race in hopes to send a message to a far-off world in another timeline. The scientists of Alpha Prime have used all their technology to reach the Ring Galaxy which promises to bring prosperity to the hungry worlds of Alpha Prime. They set out with three ships from different corporations. Each group has its own agenda which causes a disaster.
Only Mrs. Nightshade knows the truth about the dangers that live in Ring Galaxy. She becomes obsessed with saving the human race.
Humankind falls by bringing its own demise because of greed and its hunger to dominate weaker beings. Humans have developed clones and cyborgs in hopes of building the first Earth-type colony in another planet. But Mrs. Nightshade knows that the creatures on this planet are more powerful. She attempts to intervene, only to bring more danger to Alpha Prime. She attracts dark forces deadlier than anything humans can imagine. A few allies with telepathic abilities see the new danger. However, they are spread throughout time and space.
They start the long process to free humans and other races from their evil captors. They know the dangers of altering time, but they still try to slowly integrate into the human race through their DNA. They use ancient Earth to bring out the first human hybrid to eventually battle the dark forces at the final battle.